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The effect of these channels on neuron firing level in nigral dopamine neurons is such that administration of the KATP-channel antagonist glibenclamide in a 100 nM focus was able to enhance neuron firing level by 34% (Garcia de Arriba et al 1999; Avshalumov et al 2005). KATP-channel action also seems to get amplified by extracellular adenosine by u